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If you use any over-the-counter (OTC) medicine, including vitamins, herbal or food supplements, be sure to review these products for interactions with your prescription medications, too.

How often a drug interaction occurs, and your risk for a drug interaction, also depends upon factors such as: Don’t forget that alcohol, caffeine, and illegal drugs of abuse can lead to serious drug interactions, too.For example, taking a pain medication such as hydrocodone-acetaminophen (Vicodin) with alcohol can cause additive drowsiness, may dangerously decrease your breathing rate, and in large doses may be toxic to the liver due to the combination of acetaminophen (Tylenol) and alcohol.Taking a medication that was prescribed for someone else or bought off of the Internet can be dangerous, too and lead to unexpected drug interactions. Communication with your healthcare provider is key in helping to prevent drug interactions.Stop drinking immediately if you're feeling sick or having difficulty walking or talking. Be aware that sedatives can be added to drinks (even non-alcoholic drinks), leaving students vulnerable to sexual assault.Never leave a drink unattended at a bar or party and never accept drinks from people you don't know.

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This tool explains what the interaction is, how it occurs, the level of significance (major, moderate, or minor) and usually a suggested course of action.