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Posted by / 09-Jul-2017 08:17

Elucidating protein function

In the mid 1950's scientists observed a new specialized cellular compartment, called an " and functions as a workstation for degradation of cellular constituents.

The Belgian scientist Christian de Duve was awarded the Nobel Prize in Physiology or Medicine in 1974 for the discovery of the lysosome.

The vesicles were autophagosomes and Ohsumi's experiment proved that authophagy exists in yeast cells.

The cell therefore appeared to have a strategy for delivering large cargo to the lysosome.

In this review, we attempt to give a concise overview of recent progress made in mechanistic understanding of protein aggregation, particulate formation and protein solution rheology.

Recent advances in analytical techniques and methods for characterizing protein aggregation and the formed protein particles as well as advancements, technique limitations and controversies in the field of protein solution rheology are discussed.

He then went on to elucidate the underlying mechanisms for autophagy in yeast and showed that similar sophisticated machinery is used in our cells.

Ohsumi's discoveries led to a new paradigm in our understanding of how the cell recycles its content.

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